OPHTHALMIC SYMPTOMS OF LEMS

Keep your eyes open for LEMS in your practice

Lambert-Eaton myasthenic syndrome (LEMS) is a rare, immune-mediated neuromuscular disorder characterized by ^5,6,12:

Proximal muscle weakness

Autonomic symptoms

Hyporeflexia or areflexia

ABOUT 50% OF PATIENTS WITH LEMS ALSO PRESENT WITH OCULOBULBAR SYMPTOMS¹²

Commonly reported symptoms include ^25,26 :

Ptosis

Diplopia

Other signs and symptoms may occur in patients with LEMS such as disconjugate gaze, involuntary lid closure, prolonged upgaze, dilated pupils, and poorly reactive pupils.^25,27

The frequency of ocular symptoms may increase as LEMS progresses²⁶

One study found that symptoms increased from 5% at disease onset to 42% at 6 months post onset²⁶

As a neuro-ophthalmologist, you can play a vital role in identifying, diagnosing, and treating LEMS.

IF YOU SUSPECT YOUR PATIENT MAY HAVE LEMS,
ORDER A FREE LEMS TEST.

LEARN MORE ABOUT FIRDAPSE® (AMIFAMPRIDINE)—THE RECOMMENDED
FIRST-LINE THERAPY FOR LEMS.¹

OPHTHAMOLOGY FLASHCARD

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and more using the link below.

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LEMS POP QUIZ

Which of these ophthalmic symptoms are most commonly seen in patients with LEMS? (please select two)

Disconjugate gaze

Diplopia

Prolonged upgaze

Ptosis

NEXT: Treating LEMS

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Indication and Important Safety Information

INDICATIONS AND USAGE:

FIRDAPSE is a potassium channel blocker indicated for the treatment of Lambert-Eaton myasthenic syndrome (LEMS) in adults and pediatric patients 6 years of age and older.

CONTRAINDICATIONS

FIRDAPSE is contraindicated in patients with:

A history of seizures
Hypersensitivity to amifampridine phosphate or another aminopyridine

WARNINGS AND PRECAUTIONS

Seizures: FIRDAPSE can cause seizures. Consider discontinuation or dose-reduction of FIRDAPSE in patients who have a seizure while on treatment.

Hypersensitivity: If a hypersensitivity reaction such as anaphylaxis occurs, FIRDAPSE should be discontinued and appropriate therapy initiated.

ADVERSE REACTIONS

The most common (> 10%) adverse reactions are: paresthesia, upper respiratory tract infection, abdominal pain, nausea, diarrhea, headache, elevated liver enzymes, back pain, hypertension, and muscle spasms.

Please see full Prescribing Information for additional Important Safety Information.

To report SUSPECTED ADVERSE REACTIONS, contact Catalyst Pharmaceuticals at 1-844-347-3277 (1-844-FIRDAPSE) or FDA at 1-800-FDA-1088 or www.fda.gov/medwatch.

References:

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Oh SJ, Scherbakova N, Kostera-Pruszczyk A, et al; LEMS Study Group. Amifampridine phosphate (FIRDAPSE®) is effective and safe in a phase 3 clinical trial in LEMS. Muscle Nerve. 2016;53(5):717-725.
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