{"id":46,"date":"2025-06-19T19:00:34","date_gmt":"2025-06-19T19:00:34","guid":{"rendered":"https:\/\/firdapsehcp-calems.local\/calems\/?page_id=36"},"modified":"2026-03-20T17:22:11","modified_gmt":"2026-03-20T17:22:11","slug":"firdapse-dosing","status":"publish","type":"page","link":"https:\/\/firdapsehcp.com\/ca-lems\/firdapse-dosing\/","title":{"rendered":"FIRDAPSE Dosing"},"content":{"rendered":"\n<p class=\"has-medium-font-size em-mb--md\"><strong>For patients \u22656 years of age and weighing \u226545 kg<sup>1<\/sup><\/strong><\/p>\n\n\n\t\t\t\t<div id=\"block_823302e12ce7c3caf2d41294083191df\" class=\"wp-block em-rounded-corner-block em-mt--none em-mb--xl alignwide\">\n\t\t\t\t\t\t\t\t\t\t\n\t<div class=\"em-rounded-corner-block__background-image\">\n\t\t<img decoding=\"async\" src=\"https:\/\/firdapsehcp.com\/ca-lems\/wp-content\/uploads\/sites\/2\/2025\/06\/Group-15810.svg\"\n\t\t\talt=\"\">\n\t<\/div>\n\n<div class=\"em-rounded-corner-block__wrapper has-none-background-color\">\n\t\n\n<div class=\"wp-block-emagine-grid wp-block-emagine-grid--thirds verticalBorders\"><div class=\"wp-block-emagine-grid__inner em-grid-3_sm-1-left verticalBorders\">\n<div class=\"wp-block-emagine-column em-col\">\n<div class=\"wp-block-image aligncenter size-full\"><div><figure class=\"\"><img loading=\"lazy\" decoding=\"async\" width=\"54\" height=\"54\" src=\"https:\/\/firdapsehcp.com\/ca-lems\/wp-content\/uploads\/sites\/2\/2025\/07\/Group-15323.png\" alt=\"\" class=\"wp-image-253\"\/><\/figure><\/div><\/div>\n\n\n\n<h3 class=\"no-transform has-blue-d-color has-text-color has-link-color em-mt--sm em-mb--none has-text-align-center h3 wp-elements-0293db9b2e373d8df50038d0b5300b96\">Start<\/h3>\n\n\n\n<h3 class=\"has-weight-extra-bold has-largest-font-size has-blue-d-color has-text-color has-link-color em-mt--md em-mb--none has-text-align-center h2 wp-elements-1e82c04194edfe5feb07f0e45e29077c\">15-30<\/h3>\n\n\n\n<p class=\"has-text-align-center has-medium-font-size em-mt--none em-mb--none\"><strong>mg\/day<\/strong><\/p>\n\n\n\n<p class=\"has-text-align-center em-mt--none em-mb--none\">in divided doses<br>3 to 5 times\/day<\/p>\n\n\n\n<p class=\"has-text-align-center\"><strong>Recommended<\/strong><br>starting total daily<br>dosage of FIRDAPSE<sup>1<\/sup><\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-emagine-column em-col\">\n<div class=\"wp-block-image aligncenter size-full\"><div><figure class=\"\"><img loading=\"lazy\" decoding=\"async\" width=\"54\" height=\"54\" src=\"https:\/\/firdapsehcp.com\/ca-lems\/wp-content\/uploads\/sites\/2\/2025\/07\/Group-15324.png\" alt=\"\" class=\"wp-image-254\"\/><\/figure><\/div><\/div>\n\n\n\n<h3 class=\"no-transform has-blue-d-color has-text-color has-link-color em-mt--sm em-mb--none has-text-align-center h3 wp-elements-b2a468dd5bf7c722293d25bce1e9b6aa\">Titrate<\/h3>\n\n\n\n<h3 class=\"has-weight-extra-bold has-largest-font-size has-blue-d-color has-text-color has-link-color em-mt--md em-mb--none has-text-align-center h2 wp-elements-bc069345d8584d7557973f09e456e842\">+5<\/h3>\n\n\n\n<p class=\"has-text-align-center has-medium-font-size em-mt--none em-mb--none\"><strong>mg\/day<\/strong><\/p>\n\n\n\n<p class=\"has-text-align-center\"><strong>Titrate dosage up<\/strong><br>every 3 or 4 days<sup>1<\/sup><\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-emagine-column em-col\">\n<div class=\"wp-block-image aligncenter size-full\"><div><figure class=\"\"><img loading=\"lazy\" decoding=\"async\" width=\"54\" height=\"54\" src=\"https:\/\/firdapsehcp.com\/ca-lems\/wp-content\/uploads\/sites\/2\/2025\/06\/Group-15325.png\" alt=\"\" class=\"wp-image-141\"\/><\/figure><\/div><\/div>\n\n\n\n<h3 class=\"no-transform has-blue-d-color has-text-color has-link-color em-mt--sm em-mb--none has-text-align-center h3 wp-elements-99d80aa80b47b6d0d77514f4ae103cc9\">Escalate<\/h3>\n\n\n\n<p class=\"has-text-align-center em-mt--none em-mb--none\">(as needed)<\/p>\n\n\n\n<p class=\"has-text-align-center em-mt--sm em-mb--none\">Up to a maximum of<\/p>\n\n\n\n<h3 class=\"has-weight-extra-bold has-largest-font-size has-blue-d-color has-text-color has-link-color em-mt--none em-mb--none has-text-align-center h2 wp-elements-49b596894822715552125f4146f3d38e\">100<\/h3>\n\n\n\n<p class=\"has-text-align-center has-medium-font-size em-mt--none em-mb--none\"><strong>mg\/day<\/strong><\/p>\n\n\n\n<p class=\"has-text-align-center\"><strong>or until optimal dose is achieved<\/strong><br>with acceptable tolerance<sup>1<\/sup><\/p>\n<\/div>\n<\/div><\/div>\n\n\n<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\n\n\n<p class=\"\"><strong>Assist your patients to reach their optimal therapeutic dose<\/strong><\/p>\n\n\n\n<p class=\"\">For new patients who are just getting started on FIRDAPSE and have not taken amifampridine before, titration is an important step. Guiding your patients through the titration process can help:<\/p>\n\n\n<?xml encoding=\"UTF-8\"><ul class=\"wp-block-list em-mb--lg\">\n<li class=\"\"><span class=\"list-item-text\">Determine their optimal therapeutic dose of FIRDAPSE<\/span><\/li>\n\n\n\n<li class=\"\"><span class=\"list-item-text\">Maximize neuromuscular benefit<\/span><\/li>\n\n\n\n<li class=\"\"><span class=\"list-item-text\">Minimize issues with tolerability, including paresthesia<\/span><\/li>\n<\/ul>\n\n\n\t\t\t\t<div id=\"block_275b718cf185d92b6e637f0c792cdb63\" class=\"wp-block em-rounded-corner-block em-mt--xl em-mb--xl alignwide\">\n\t\t\t\t\t\t\t\t\t\t\n\n<div class=\"em-rounded-corner-block__wrapper has-none-background-color no-padding\">\n\t\n\n<div class=\"wp-block-emagine-grid wp-block-emagine-grid--right-heavy\"><div class=\"wp-block-emagine-grid__inner em-grid-left-middle-alternateRows\">\n<div class=\"wp-block-emagine-column em-col-4_sm-12-middle image-cover\">\n<div class=\"wp-block-image size-full em-hide--sm-down\"><div><figure class=\"\"><img loading=\"lazy\" decoding=\"async\" width=\"313\" height=\"401\" src=\"https:\/\/firdapsehcp.com\/ca-lems\/wp-content\/uploads\/sites\/2\/2025\/07\/07_Image_FatherSon_Desktop.png\" alt=\"\" class=\"wp-image-176\" srcset=\"https:\/\/firdapsehcp.com\/ca-lems\/wp-content\/uploads\/sites\/2\/2025\/07\/07_Image_FatherSon_Desktop.png 313w, https:\/\/firdapsehcp.com\/ca-lems\/wp-content\/uploads\/sites\/2\/2025\/07\/07_Image_FatherSon_Desktop-234x300.png 234w, https:\/\/firdapsehcp.com\/ca-lems\/wp-content\/uploads\/sites\/2\/2025\/07\/07_Image_FatherSon_Desktop-100x128.png 100w\" sizes=\"auto, (max-width: 313px) 100vw, 313px\" \/><\/figure><\/div><\/div>\n\n\n\n<div class=\"wp-block-image aligncenter size-full em-hide--sm-up\"><div><figure class=\"\"><img loading=\"lazy\" decoding=\"async\" width=\"318\" height=\"402\" src=\"https:\/\/firdapsehcp.com\/ca-lems\/wp-content\/uploads\/sites\/2\/2025\/07\/07_Image_FatherSon_Mobile.png\" alt=\"\" class=\"wp-image-177\" srcset=\"https:\/\/firdapsehcp.com\/ca-lems\/wp-content\/uploads\/sites\/2\/2025\/07\/07_Image_FatherSon_Mobile.png 318w, https:\/\/firdapsehcp.com\/ca-lems\/wp-content\/uploads\/sites\/2\/2025\/07\/07_Image_FatherSon_Mobile-237x300.png 237w, https:\/\/firdapsehcp.com\/ca-lems\/wp-content\/uploads\/sites\/2\/2025\/07\/07_Image_FatherSon_Mobile-100x126.png 100w\" sizes=\"auto, (max-width: 318px) 100vw, 318px\" \/><\/figure><\/div><\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-emagine-column em-col-8_sm-12-middle\">\n<h3 class=\"no-transform has-blue-d-color has-text-color has-link-color h3 wp-elements-34e53dabf0cf27487086420d91c8ad44\">FIRDAPSE is now approved for maximum dosing up to 100 mg\/day<\/h3>\n\n\n\n<p class=\"\">The FDA has approved an increase in the maximum daily dose for FIRDAPSE from 80 mg to 100 mg. This expanded ceiling ensures patients taking higher doses of FIRDAPSE can still benefit from dose titration, when their symptoms progress and worsen, and warrant a dosing increase to achieve or maintain an optimal therapeutic effect.<sup>24<\/sup><\/p>\n<\/div>\n<\/div><\/div>\n\n\n<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\n\n\n<p class=\"has-medium-font-size\"><strong>Additional dosing information<\/strong><\/p>\n\n\n<?xml encoding=\"UTF-8\"><ul class=\"wp-block-list em-mb--lg\">\n<li class=\"\"><span class=\"list-item-text\">FIRDAPSE tablets can be taken with or without food<sup>1<\/sup><\/span><\/li>\n\n\n\n<li class=\"\"><span class=\"list-item-text\">Scored tablets can be split with a pill splitter as needed<sup>1<\/sup><br>NOTE: If you have dosing adjustments &lt;5 mg or have patients with trouble swallowing a tablet, a suspension can be prepared. Refer to the&nbsp;Medication Guide&nbsp;for instructions on suspension preparation<sup>1<\/sup><\/span><\/li>\n\n\n\n<li class=\"\"><span class=\"list-item-text\">If a dose is missed, patients should not take double or extra doses<sup>1<\/sup><\/span><\/li>\n\n\n\n<li class=\"\"><span class=\"list-item-text\">Patients newly treated with amifampridine should be advised that based on clinical trial observations, they may experience transient paresthesia, but this side effect is expected to diminish with continued treatment<sup>1,2<\/sup><\/span><\/li>\n<\/ul>\n\n\n\n<div class=\"wp-block-emagine-background alignfull has-gray-xl-background-color has-background-dim em-pt--md em-pb--lg has-background em-mb--lg em-pt--md em-pb--lg\"><div class=\"wp-block-emagine-background__content\"><div class=\"wp-block-emagine-background__content-inner\">\n<div class=\"wp-block-emagine-grid wp-block-emagine-grid--halves\"><div class=\"wp-block-emagine-grid__inner em-grid-2_sm-1-equalHeight-left\">\n<div class=\"wp-block-emagine-column em-col\">\n<p class=\"has-medium-font-size\"><strong>How FIRDAPSE is supplied<\/strong><\/p>\n\n\n\n<p class=\"\">FIRDAPSE is dispensed in both bottles and child-resistant blister packs, making it easy for you and your patients to choose the best option for them.<\/p>\n\n\n\n<p class=\"has-blue-d-color has-text-color has-link-color wp-elements-522e271559c7f2b41de545709a7b2317\"><strong>Bottles<sup>1<\/sup><\/strong><\/p>\n\n\n<?xml encoding=\"UTF-8\"><ul class=\"wp-block-list\">\n<li class=\"\"><span class=\"list-item-text\">Containing 60 or 240 tablets<\/span><\/li>\n<\/ul>\n\n\n\n<p class=\"has-blue-d-color has-text-color has-link-color wp-elements-8253a806cb368ea30c0d9a2908ab484c\"><strong>Blister packs<sup>1<\/sup><\/strong><\/p>\n\n\n<?xml encoding=\"UTF-8\"><ul class=\"wp-block-list\">\n<li class=\"\"><span class=\"list-item-text\">Individual pack containing 10 tablets<\/span><\/li>\n\n\n\n<li class=\"\"><span class=\"list-item-text\">Carton containing 12 packs (120 tablets total)<\/span><\/li>\n<\/ul>\n<\/div>\n\n\n\n<div class=\"wp-block-emagine-column em-col\">\t\t\t\t<div id=\"block_d2c92f98e88c0d5e676836bca37afa9a\" class=\"wp-block em-rounded-corner-block em-mt--none em-mb--md alignwide\">\n\t\t\t\t\t\t\t\t\t\t\n\n<div class=\"em-rounded-corner-block__wrapper has-none-background-color\">\n\t\n\n<div class=\"wp-block-image aligncenter size-full em-mt--none em-mb--none em-pt--sm em-pb--none\"><div><figure class=\"\"><img decoding=\"async\" src=\"https:\/\/firdapsehcp.com\/ca-lems\/wp-content\/uploads\/sites\/2\/2025\/09\/Combo_Bottle_and_Package_4cp_silho_HRsm.png\" alt=\"\" class=\"wp-image-321\"\/><\/figure><\/div><\/div>\n\n\n<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n<\/div><\/div>\n<\/div><\/div><\/div>\n\n\n\n<p class=\"em-mb--lg\"><\/p>\n\n\n\t\t\t\t<div id=\"block_bd805b311278a2ac7f73b4ab95a9bdb8\" class=\"wp-block em-rounded-corner-block em-mt--xl em-mb--xl alignwide\">\n\t\t\t\t\t\t\t\t\t\t\n\n<div class=\"em-rounded-corner-block__wrapper has-none-background-color\">\n\t\n\n<div class=\"wp-block-emagine-grid wp-block-emagine-grid--right-heavy pregnancyCTA verticalBorders\"><div class=\"wp-block-emagine-grid__inner em-grid-left-middle-alternateRows verticalBorders\">\n<div class=\"wp-block-emagine-column em-col-4_sm-12-middle\">\n<div class=\"wp-block-image aligncenter size-large em-mb--none\"><div><figure class=\"\"><img decoding=\"async\" src=\"https:\/\/firdapsehcp.com\/ca-lems\/wp-content\/uploads\/sites\/2\/2025\/06\/Group-15382.svg\" alt=\"\" class=\"wp-image-29\"\/><\/figure><\/div><\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-emagine-column em-col-8_sm-12-middle\">\n<p class=\"has-blue-d-color has-text-color has-link-color has-medium-font-size wp-elements-8107cdca073b52abb73b3995a11d51fa\"><strong>Do you have a patient taking FIRDAPSE who is pregnant?<\/strong><\/p>\n\n\n\n<p class=\"has-base-text-gray-color has-text-color has-link-color wp-elements-2537758feb5e54810bcc39cac1f63516\"><strong>The FIRDAPSE Pregnancy Registry<sup>1<\/sup>:<\/strong> In conjunction with the FDA, Catalyst Pharmaceuticals has created a registry to collect information about the safety of FIRDAPSE use during pregnancy. Enroll patients with LEMS\u2014even those not taking FIRDAPSE\u2014as soon as you learn of their pregnancy by calling <a href=\"tel:18552125856\">1-855-212-5856<\/a> or visiting <a data-type=\"link\" data-id=\"www.firdapsepregnancystudy.com\" href=\"https:\/\/www.firdapsepregnancystudy.com\/\" target=\"_blank\" rel=\"noopener\">www.firdapsepregnancystudy.com<\/a><\/p>\n<\/div>\n<\/div><\/div>\n\n\n<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\n\n\n<p class=\"em-mb--lg\"><\/p>\n\n\n\n<div class=\"wp-block-emagine-grid alignwide wp-block-emagine-grid--halves footer-cta-cards\"><div class=\"wp-block-emagine-grid__inner em-grid-2_sm-1-equalHeight-left-middle\">\n<div class=\"wp-block-emagine-column em-col-middle\">\t\t\t\t<div id=\"block_f1e0fc922756810b6e15cfa14f72647e\" class=\"wp-block em-cta-card em-mt--none em-mb--md alignwide\">\n\t\t\t\t\t\t\t\t\t\t\n<div class=\"em-cta-card__wrapper icon-above\">\n\t<div class=\"em-cta-card__heading\">\n\t\t\t\t<img decoding=\"async\" src=\"https:\/\/firdapsehcp.com\/ca-lems\/wp-content\/uploads\/sites\/2\/2025\/07\/Group-15057.svg\" class=\"em-cta-card__icon\" \/>\n\t<\/div>\n\n\t<div class=\"em-cta-card__content\">\n\t\t\t\t\t<h3 class=\"em-cta-card__title\">Request a Rep<\/h3>\n\t\t\t\t<p>Connect with a FIRDAPSE<br \/>\nrepresentative.<\/p>\n\t<\/div>\n\n\t<div class=\"em-cta-card__btn-wrapper\">\n\t\t<a href=\"https:\/\/firdapsehcp.com\/ca-lems\/request-a-rep\/\" target=\"\" class=\"c-btn c-btn--fwd\">\n\t\t\tStart Request\t\t<\/a>\n\t<\/div>\n<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\n\n\n<div class=\"wp-block-emagine-column em-col-middle\">\t\t\t\t<div id=\"block_a627798b71b600f639cfeff9dbd63618\" class=\"wp-block em-cta-card em-mt--none em-mb--md alignwide\">\n\t\t\t\t\t\t\t\t\t\t\n<div class=\"em-cta-card__wrapper icon-above\">\n\t<div class=\"em-cta-card__heading\">\n\t\t\t\t<img decoding=\"async\" src=\"https:\/\/firdapsehcp.com\/ca-lems\/wp-content\/uploads\/sites\/2\/2025\/06\/Group-15384.svg\" class=\"em-cta-card__icon\" \/>\n\t<\/div>\n\n\t<div class=\"em-cta-card__content\">\n\t\t\t\t\t<h3 class=\"em-cta-card__title\">Affordability<\/h3>\n\t\t\t\t<p>Learn how to help patients<br \/>\nafford their medication.<\/p>\n\t<\/div>\n\n\t<div class=\"em-cta-card__btn-wrapper\">\n\t\t<a href=\"https:\/\/firdapsehcp.com\/ca-lems\/affordability\/\" target=\"\" class=\"c-btn c-btn--fwd\">\n\t\t\tGo to Affordability\t\t<\/a>\n\t<\/div>\n<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n<\/div><\/div>\n","protected":false},"excerpt":{"rendered":"<p>For patients \u22656 years of age and weighing \u226545 kg1 Assist your patients to reach their optimal therapeutic dose For&#8230;<\/p>\n","protected":false},"author":2,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":true,"em_featured_video_id":0,"footnotes":""},"class_list":["post-46","page","type-page","status-publish","hentry"],"acf":[],"_links":{"self":[{"href":"https:\/\/firdapsehcp.com\/ca-lems\/wp-json\/wp\/v2\/pages\/46","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/firdapsehcp.com\/ca-lems\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/firdapsehcp.com\/ca-lems\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/firdapsehcp.com\/ca-lems\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/firdapsehcp.com\/ca-lems\/wp-json\/wp\/v2\/comments?post=46"}],"version-history":[{"count":0,"href":"https:\/\/firdapsehcp.com\/ca-lems\/wp-json\/wp\/v2\/pages\/46\/revisions"}],"wp:attachment":[{"href":"https:\/\/firdapsehcp.com\/ca-lems\/wp-json\/wp\/v2\/media?parent=46"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}