{"id":42,"date":"2025-06-19T18:59:45","date_gmt":"2025-06-19T18:59:45","guid":{"rendered":"https:\/\/firdapsehcp-calems.local\/calems\/?page_id=32"},"modified":"2025-12-17T16:31:27","modified_gmt":"2025-12-17T16:31:27","slug":"vgcc-ab-test","status":"publish","type":"page","link":"https:\/\/firdapsehcp.com\/ca-lems\/vgcc-ab-test\/","title":{"rendered":"VGCC-Ab Test"},"content":{"rendered":"\n<p class=\"em-mb--lg\">A VGCC-Ab test, both P\/Q and N types, may be a key tool for the diagnosis of Cancer-Associated Lambert-Eaton myasthenic syndrome (LEMS) SCLC.<sup>5,6<\/sup><\/p>\n\n\n\n<div class=\"wp-block-emagine-background alignfull has-gray-xl-background-color has-background-dim em-pt--md em-pb--lg has-background em-mb--lg em-pt--md em-pb--lg\"><div class=\"wp-block-emagine-background__content\"><div class=\"wp-block-emagine-background__content-inner\">\n<h2 class=\"has-blue-d-color has-text-color has-link-color em-mb--md h2 wp-elements-13e568d2db405abfbc3865351170f83d\">Timely DIAGNOSIS IS KEY TO AVOIDING THESE POTENTIAL CONSEQUENCES<\/h2>\n\n\n\n<p class=\"em-mb--md\">Timely testing for LEMS is important. Patients with Cancer-Associated LEMS SCLC have a different prognosis than those with SCLC without LEMS, and the associated proximal muscle weakness is treatable.<sup>5,15<\/sup><\/p>\n\n\n\n<div class=\"wp-block-emagine-grid alignwide wp-block-emagine-grid--thirds verticalBorders\"><div class=\"wp-block-emagine-grid__inner em-grid-3_sm-1-left-middle verticalBorders\">\n<div class=\"wp-block-emagine-column em-col-middle\">\n<div class=\"wp-block-image aligncenter size-full\"><div><figure class=\"\"><img loading=\"lazy\" decoding=\"async\" width=\"99\" height=\"120\" src=\"https:\/\/firdapsehcp.com\/ca-lems\/wp-content\/uploads\/sites\/2\/2025\/07\/03_Icon_Spread_Severity.png\" alt=\"\" class=\"wp-image-165\"\/><\/figure><\/div><\/div>\n\n\n\n<p class=\"has-text-align-center\"><strong>Spread and severity of <\/strong><br><strong>symptoms<sup>4,12<\/sup><\/strong><\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-emagine-column em-col-middle\">\n<div class=\"wp-block-image aligncenter size-full\"><div><figure class=\"\"><img loading=\"lazy\" decoding=\"async\" width=\"118\" height=\"118\" src=\"https:\/\/firdapsehcp.com\/ca-lems\/wp-content\/uploads\/sites\/2\/2025\/07\/03_Icon_Wheelchair.png\" alt=\"\" class=\"wp-image-166\" srcset=\"https:\/\/firdapsehcp.com\/ca-lems\/wp-content\/uploads\/sites\/2\/2025\/07\/03_Icon_Wheelchair.png 118w, https:\/\/firdapsehcp.com\/ca-lems\/wp-content\/uploads\/sites\/2\/2025\/07\/03_Icon_Wheelchair-100x100.png 100w\" sizes=\"auto, (max-width: 118px) 100vw, 118px\" \/><\/figure><\/div><\/div>\n\n\n\n<p class=\"has-text-align-center\"><strong>Loss of function and <\/strong><br><strong>mobility<sup>12<\/sup><\/strong><\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-emagine-column em-col-middle\">\n<div class=\"wp-block-image aligncenter size-full\"><div><figure class=\"\"><img loading=\"lazy\" decoding=\"async\" width=\"84\" height=\"120\" src=\"https:\/\/firdapsehcp.com\/ca-lems\/wp-content\/uploads\/sites\/2\/2025\/07\/03_Icon_QOL.png\" alt=\"\" class=\"wp-image-164\"\/><\/figure><\/div><\/div>\n\n\n\n<p class=\"has-text-align-center\"><strong>Loss of independence and <\/strong><br><strong>quality of life<sup>12<\/sup><\/strong><\/p>\n<\/div>\n<\/div><\/div>\n<\/div><\/div><\/div>\n\n\n\n<h2 class=\"no-transform has-blue-d-color has-text-color has-link-color em-mb--md h2 wp-elements-198a2f6c1263785e1213812dd8f24ade\">WHY COMPREHENSIVE VGCC-Ab TESTING MATTERS<\/h2>\n\n\n<?xml encoding=\"UTF-8\"><ul class=\"wp-block-list em-mb--lg\">\n<li class=\"\"><span class=\"list-item-text\">VGCC antibodies are found in 85%-90% of LEMS patients and virtually all patients with Cancer-Associated LEMS SCLC<sup>4<\/sup><\/span><\/li>\n\n\n\n<li class=\"\"><span class=\"list-item-text\">The VGCC-Ab blood test is &gt;90% sensitive and is a critical tool to confirm a Cancer-Associated LEMS SCLC diagnosis<sup>20<\/sup><\/span><\/li>\n<\/ul>\n\n\n\t\t\t\t<div id=\"block_ce01738d8b2744801c9c47498523fb66\" class=\"wp-block em-rounded-corner-block em-mt--none em-mb--md alignwide\">\n\t\t\t\t\t\t\t\t\t\t\n\n<div class=\"em-rounded-corner-block__wrapper has-gray-xl-background-color\">\n\t\n\n<p class=\"\"><strong>Multiple types of VGCCs have been described in both the central and peripheral nervous systems. Two different VGCC antibodies are most commonly associated with Cancer-Associated LEMS SCLC: P\/Q and N types<sup>6,21<\/sup><\/strong><\/p>\n\n\n<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\n\n\n<div class=\"wp-block-emagine-background alignfull has-background-dim em-pt--sm em-pb-- em-pt--sm\"><picture><source srcset=\"https:\/\/firdapsehcp.com\/ca-lems\/wp-content\/uploads\/sites\/2\/2025\/07\/08_AFFORDABILITY-Lines-2-Outlined.svg\" media=\"(max-width: 640px)\"\/><source srcset=\"https:\/\/firdapsehcp.com\/ca-lems\/wp-content\/uploads\/sites\/2\/2025\/07\/08_AFFORDABILITY-Lines-2-Outlined.svg\" media=\"(max-width: 1120px)\"\/><img decoding=\"async\" class=\"wp-block-emagine-background__media wp-image-215\" alt=\"\" src=\"https:\/\/firdapsehcp.com\/ca-lems\/wp-content\/uploads\/sites\/2\/2025\/07\/08_AFFORDABILITY-Lines-2-Outlined.svg\"\/><\/picture><div class=\"wp-block-emagine-background__content\"><div class=\"wp-block-emagine-background__content-inner\">\t\t\t\t<div id=\"block_be070d65cd4caadd1fb532e8db9f136b\" class=\"wp-block em-cta-card em-mt--none em-mb--xl alignwide\">\n\t\t\t\t\t\t\t\t\t\t\n<div class=\"em-cta-card__wrapper icon-beside\">\n\t<div class=\"em-cta-card__heading\">\n\t\t\t\t<img decoding=\"async\" src=\"https:\/\/firdapsehcp.com\/ca-lems\/wp-content\/uploads\/sites\/2\/2025\/06\/Group-15350.svg\" class=\"em-cta-card__icon\" \/>\n\t<\/div>\n\n\t<div class=\"em-cta-card__content\">\n\t\t\t\t\t<h3 class=\"em-cta-card__title\">Catalyst Pharmaceuticals recommends VGCC-Ab testing<\/h3>\n\t\t\t\t<p>In collaboration with a national diagnostic lab provider, Catalyst recommends VGCC-Ab testing, both P\/Q and N types, for patients who have symptoms suggestive of Cancer-Associated LEMS SCLC.<\/p>\n\t<\/div>\n\n\t<div class=\"em-cta-card__btn-wrapper\">\n\t\t<a href=\"https:\/\/firdapsehcp.com\/ca-lems\/diagnostic-testing\/\" target=\"\" class=\"c-btn c-btn--fwd\">\n\t\t\tOrder a Test\t\t<\/a>\n\t<\/div>\n<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div><\/div><\/div>\n\n\n\n<div class=\"wp-block-emagine-grid alignwide wp-block-emagine-grid--halves footer-cta-cards\"><div class=\"wp-block-emagine-grid__inner em-grid-2_sm-1-equalHeight-left-middle\">\n<div class=\"wp-block-emagine-column em-col-middle\">\t\t\t\t<div id=\"block_cdf9c6051ebf5677a7b382c71b361d9d\" class=\"wp-block em-cta-card em-mt--none em-mb--md alignwide\">\n\t\t\t\t\t\t\t\t\t\t\n<div class=\"em-cta-card__wrapper icon-above\">\n\t<div class=\"em-cta-card__heading\">\n\t\t\t\t<img decoding=\"async\" src=\"https:\/\/firdapsehcp.com\/ca-lems\/wp-content\/uploads\/sites\/2\/2025\/07\/Group-15057.svg\" class=\"em-cta-card__icon\" \/>\n\t<\/div>\n\n\t<div class=\"em-cta-card__content\">\n\t\t\t\t\t<h3 class=\"em-cta-card__title\">Request a Rep<\/h3>\n\t\t\t\t<p>Connect with a FIRDAPSE<br \/>\nrepresentative.<\/p>\n\t<\/div>\n\n\t<div class=\"em-cta-card__btn-wrapper\">\n\t\t<a href=\"https:\/\/firdapsehcp.com\/ca-lems\/request-a-rep\/\" target=\"\" class=\"c-btn c-btn--fwd\">\n\t\t\tStart Request\t\t<\/a>\n\t<\/div>\n<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\n\n\n<div class=\"wp-block-emagine-column em-col-middle\">\t\t\t\t<div id=\"block_5473e750d1baeaf2edcba2f1a8730ccc\" class=\"wp-block em-cta-card em-mt--none em-mb--md alignwide\">\n\t\t\t\t\t\t\t\t\t\t\n<div class=\"em-cta-card__wrapper icon-above\">\n\t<div class=\"em-cta-card__heading\">\n\t\t\t\t<img decoding=\"async\" src=\"https:\/\/firdapsehcp.com\/ca-lems\/wp-content\/uploads\/sites\/2\/2025\/06\/Group-15424.png\" class=\"em-cta-card__icon\" \/>\n\t<\/div>\n\n\t<div class=\"em-cta-card__content\">\n\t\t\t\t\t<h3 class=\"em-cta-card__title\">About FIRDAPSE<\/h3>\n\t\t\t\t<p>Discover the only clinically proven FDA-approved<br \/>\ntreatment for Cancer-Associated LEMS SCLC.<\/p>\n\t<\/div>\n\n\t<div class=\"em-cta-card__btn-wrapper\">\n\t\t<a href=\"https:\/\/firdapsehcp.com\/ca-lems\/about-firdapse\/\" target=\"\" class=\"c-btn c-btn--fwd\">\n\t\t\tGo to About FIRDAPSE\t\t<\/a>\n\t<\/div>\n<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n<\/div><\/div>\n","protected":false},"excerpt":{"rendered":"<p>A VGCC-Ab test, both P\/Q and N types, may be a key tool for the diagnosis of Cancer-Associated Lambert-Eaton myasthenic&#8230;<\/p>\n","protected":false},"author":2,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":true,"em_featured_video_id":0,"footnotes":""},"class_list":["post-42","page","type-page","status-publish","hentry"],"acf":[],"_links":{"self":[{"href":"https:\/\/firdapsehcp.com\/ca-lems\/wp-json\/wp\/v2\/pages\/42","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/firdapsehcp.com\/ca-lems\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/firdapsehcp.com\/ca-lems\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/firdapsehcp.com\/ca-lems\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/firdapsehcp.com\/ca-lems\/wp-json\/wp\/v2\/comments?post=42"}],"version-history":[{"count":0,"href":"https:\/\/firdapsehcp.com\/ca-lems\/wp-json\/wp\/v2\/pages\/42\/revisions"}],"wp:attachment":[{"href":"https:\/\/firdapsehcp.com\/ca-lems\/wp-json\/wp\/v2\/media?parent=42"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}