{"id":41,"date":"2025-06-19T18:59:20","date_gmt":"2025-06-19T18:59:20","guid":{"rendered":"https:\/\/firdapsehcp-calems.local\/calems\/?page_id=31"},"modified":"2025-12-18T21:32:34","modified_gmt":"2025-12-18T21:32:34","slug":"signs-and-symptoms","status":"publish","type":"page","link":"https:\/\/firdapsehcp.com\/ca-lems\/signs-and-symptoms\/","title":{"rendered":"SIGNS AND SYMPTOMS"},"content":{"rendered":"\n<p class=\"em-mb--sm\"><strong>The progressive nature of Cancer-Associated LEMS SCLC and the challenges that diagnosing it can present make early symptom recognition critical for optimal patient care.<sup>16<\/sup><\/strong><\/p>\n\n\n\n<p class=\"\">Cancer-Associated LEMS SCLC is often suspected based on a clinical triad of signs and symptoms<sup>4,17<\/sup>:<\/p>\n\n\n<?xml encoding=\"UTF-8\"><ul class=\"wp-block-list\">\n<li class=\"\"><span class=\"list-item-text\">Proximal muscle weakness<\/span><\/li>\n\n\n\n<li class=\"\"><span class=\"list-item-text\">Autonomic symptoms (eg, dry mouth, impotence)<\/span><\/li>\n\n\n\n<li class=\"\"><span class=\"list-item-text\">Hyporeflexia or areflexia<\/span><\/li>\n<\/ul>\n\n\n\n<div class=\"wp-block-image alignwide size-full em-mb--xl\"><div><figure class=\"\"><img loading=\"lazy\" decoding=\"async\" width=\"1039\" height=\"765\" src=\"https:\/\/firdapsehcp.com\/ca-lems\/wp-content\/uploads\/sites\/2\/2025\/12\/Group_15474_DT.png\" alt=\"\" class=\"wp-image-432\" srcset=\"https:\/\/firdapsehcp.com\/ca-lems\/wp-content\/uploads\/sites\/2\/2025\/12\/Group_15474_DT.png 1039w, https:\/\/firdapsehcp.com\/ca-lems\/wp-content\/uploads\/sites\/2\/2025\/12\/Group_15474_DT-300x221.png 300w, https:\/\/firdapsehcp.com\/ca-lems\/wp-content\/uploads\/sites\/2\/2025\/12\/Group_15474_DT-1024x754.png 1024w, https:\/\/firdapsehcp.com\/ca-lems\/wp-content\/uploads\/sites\/2\/2025\/12\/Group_15474_DT-768x565.png 768w, https:\/\/firdapsehcp.com\/ca-lems\/wp-content\/uploads\/sites\/2\/2025\/12\/Group_15474_DT-100x74.png 100w\" sizes=\"auto, (max-width: 1039px) 100vw, 1039px\" \/><\/figure><\/div><\/div>\n\n\n\n<h2 class=\"em-mb--md h2\">LEMS AND CANCER OFTEN GO HAND IN HAND<\/h2>\n\n\n\n<div class=\"wp-block-emagine-grid wp-block-emagine-grid--right-heavy early-stack em-mb--xl verticalBorders\"><div class=\"wp-block-emagine-grid__inner em-grid-left-middle-alternateRows verticalBorders\">\n<div class=\"wp-block-emagine-column em-col-4_sm-12-middle em-pt--md em-pb--md\">\n<h2 class=\"has-weight-extra-bold has-largest-font-size has-blue-d-color has-text-color has-link-color em-mb--xs has-text-align-center h2 wp-elements-d8ff5683e65c9d242e67bfbefe4a2218\">50%-60%<\/h2>\n\n\n\n<p class=\"has-text-align-center has-medium-font-size em-mt--xs em-mb--xs\">OF LEMS CASES ARE<\/p>\n\n\n\n<p class=\"has-text-align-center has-large-font-size em-mt--xs em-mb--xs\"><strong>ASSOCIATED<\/strong><\/p>\n\n\n\n<p class=\"has-text-align-center has-medium-font-size em-mt--xs em-mb--xs\">WITH CANCER<sup>4<\/sup><\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-emagine-column em-col-8_sm-12-middle\"><?xml encoding=\"UTF-8\"><ul class=\"wp-block-list\">\n<li class=\"\"><span class=\"list-item-text\">Although most common with SCLC, LEMS may occur with other cancers<sup>6,18<\/sup><\/span><\/li>\n\n\n\n<li class=\"\"><span class=\"list-item-text\">Cancer-Associated LEMS SCLC predominantly affects men with a history of smoking who are 60 years of age or older<sup>5<\/sup><\/span><\/li>\n\n\n\n<li class=\"\"><span class=\"list-item-text\">Cancer-Associated LEMS SCLC symptoms may appear at the time of diagnosis or up to 5 years before<sup>18<\/sup>*<\/span><\/li>\n\n\n\n<li class=\"\"><span class=\"list-item-text\">Patients with LEMS associated with SCLC often display a course that progresses more rapidly vs those with LEMS not associated with cancer<sup>5,12<\/sup><\/span><\/li>\n<\/ul>\n<\/div>\n<\/div><\/div>\n\n\n\n<div class=\"wp-block-emagine-grid wp-block-emagine-grid--right-heavy early-stack em-mb--md verticalBorders\"><div class=\"wp-block-emagine-grid__inner em-grid-left-middle-alternateRows verticalBorders\">\n<div class=\"wp-block-emagine-column em-col-4_sm-12-middle em-pt--md em-pb--md\">\n<h2 class=\"has-weight-extra-bold has-largest-font-size has-blue-color has-text-color has-link-color em-mb--xs has-text-align-center h2 wp-elements-ae7274245ebcb9f8fd83cc431c103570\">40%-50%<\/h2>\n\n\n\n<p class=\"has-text-align-center has-medium-font-size em-mt--xs em-mb--xs\">OF LEMS CASES ARE<\/p>\n\n\n\n<p class=\"has-text-align-center has-large-font-size em-mt--xs em-mb--xs\"><strong>NOT ASSOCIATED<\/strong><\/p>\n\n\n\n<p class=\"has-text-align-center has-medium-font-size em-mt--xs em-mb--xs\">WITH CANCER<sup>4<\/sup><\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-emagine-column em-col-8_sm-12-middle\"><?xml encoding=\"UTF-8\"><ul class=\"wp-block-list\">\n<li class=\"\"><span class=\"list-item-text\">Age of onset is typically 35-40 years of age with no gender difference<sup>4,5<\/sup><\/span><\/li>\n\n\n\n<li class=\"\"><span class=\"list-item-text\">Occurrence increases with other autoimmune disorders<sup>5<\/sup><\/span><\/li>\n\n\n\n<li class=\"\"><span class=\"list-item-text\">Progression\/fluctuating symptoms may appear more slowly<sup>4<\/sup><\/span><\/li>\n\n\n\n<li class=\"\"><span class=\"list-item-text\">Similar life expectancy to that of a healthy individual of the same gender and age<sup>15<\/sup><\/span><\/li>\n<\/ul>\n<\/div>\n<\/div><\/div>\n\n\n\n<p class=\"has-text-align-center has-small-font-size em-mb--xl\">*Results from a multicenter study involving 133 patients with Cancer-Associated LEMS.<sup>18<\/sup><\/p>\n\n\n\n<div class=\"wp-block-emagine-background alignfull has-gray-xl-background-color has-background-dim em-pt--xl em-pb--xl has-background em-mb--none em-pt--xl em-pb--xl\" id=\"nccn\"><div class=\"wp-block-emagine-background__content\"><div class=\"wp-block-emagine-background__content-inner\">\n<div class=\"wp-block-emagine-grid alignwide wp-block-emagine-grid--halves breaks-width early-stack\"><div class=\"wp-block-emagine-grid__inner em-grid-2_sm-1-left\">\n<div class=\"wp-block-emagine-column em-col\">\n<div class=\"wp-block-image size-full em-hide--sm-down\"><div><figure class=\"\"><img loading=\"lazy\" decoding=\"async\" width=\"606\" height=\"588\" src=\"https:\/\/firdapsehcp.com\/ca-lems\/wp-content\/uploads\/sites\/2\/2025\/07\/02_Image_Doctors_Desktop.png\" alt=\"\" class=\"wp-image-162\" srcset=\"https:\/\/firdapsehcp.com\/ca-lems\/wp-content\/uploads\/sites\/2\/2025\/07\/02_Image_Doctors_Desktop.png 606w, https:\/\/firdapsehcp.com\/ca-lems\/wp-content\/uploads\/sites\/2\/2025\/07\/02_Image_Doctors_Desktop-300x291.png 300w, https:\/\/firdapsehcp.com\/ca-lems\/wp-content\/uploads\/sites\/2\/2025\/07\/02_Image_Doctors_Desktop-100x97.png 100w\" sizes=\"auto, (max-width: 606px) 100vw, 606px\" \/><\/figure><\/div><\/div>\n\n\n\n<div class=\"wp-block-image aligncenter size-full em-hide--sm-up\"><div><figure class=\"\"><img loading=\"lazy\" decoding=\"async\" width=\"290\" height=\"286\" src=\"https:\/\/firdapsehcp.com\/ca-lems\/wp-content\/uploads\/sites\/2\/2025\/07\/02_Image_Doctors_Mobile.png\" alt=\"\" class=\"wp-image-163\" srcset=\"https:\/\/firdapsehcp.com\/ca-lems\/wp-content\/uploads\/sites\/2\/2025\/07\/02_Image_Doctors_Mobile.png 290w, https:\/\/firdapsehcp.com\/ca-lems\/wp-content\/uploads\/sites\/2\/2025\/07\/02_Image_Doctors_Mobile-100x99.png 100w\" sizes=\"auto, (max-width: 290px) 100vw, 290px\" \/><\/figure><\/div><\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-emagine-column em-col\">\n<h3 class=\"no-transform has-blue-d-color has-text-color h3\">Updated NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines<sup>\u00ae<\/sup>) recommend VGCC-Ab testing, preferably in consultation with neurology, in SCLC and suspected paraneoplastic neurologic syndrome<sup>19<\/sup><\/h3>\n\n\n\n<p class=\"\"><strong>\u201cNeurologic workup, preferably in consultation with neurology, may include but not limited to tests for PQ- and N-type voltage gated calcium channel (VGCC) antibodies.\u201d<\/strong><\/p>\n\n\n\n<p class=\"\">In patients with LEMS &#8220;Consider amifampridine in consultation with neurology.&#8221;<\/p>\n\n\n\n<p class=\"\">From NCCN Guidelines<sup>\u00ae<\/sup><br>Small Cell Lung Cancer Version 2.2026<\/p>\n<\/div>\n<\/div><\/div>\n\n\n\t\t\t\t<div id=\"block_bbbfa5d1255fc27c5101bfcc59b26742\" class=\"wp-block em-cta-card em-mt--none em-mb--md alignwide\">\n\t\t\t\t\t\t\t\t\t\t\n<div class=\"em-cta-card__wrapper icon-beside\">\n\t<div class=\"em-cta-card__heading\">\n\t\t\t\t<img decoding=\"async\" src=\"https:\/\/firdapsehcp.com\/ca-lems\/wp-content\/uploads\/sites\/2\/2025\/06\/Group-15350.svg\" class=\"em-cta-card__icon\" \/>\n\t<\/div>\n\n\t<div class=\"em-cta-card__content\">\n\t\t\t\t\t<h3 class=\"em-cta-card__title\">Cancer-Associated LEMS SCLC diagnostic test available<\/h3>\n\t\t\t\t<p>A simple blood test can confirm the diagnosis of Cancer-Associated LEMS SCLC.<sup>5<\/sup><\/p>\n\t<\/div>\n\n\t<div class=\"em-cta-card__btn-wrapper\">\n\t\t<a href=\"https:\/\/firdapsehcp.com\/ca-lems\/request-a-rep\/\" target=\"\" class=\"c-btn c-btn--fwd\">\n\t\t\tContact a representative\t\t<\/a>\n\t<\/div>\n<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div><\/div><\/div>\n\n\n\n<div class=\"wp-block-emagine-grid alignwide wp-block-emagine-grid--halves footer-cta-cards\"><div class=\"wp-block-emagine-grid__inner em-grid-2_sm-1-equalHeight-left-middle\">\n<div class=\"wp-block-emagine-column em-col-middle\">\t\t\t\t<div id=\"block_efa0d5ef188d2a9de214bb78d163cfb0\" class=\"wp-block em-cta-card em-mt--none em-mb--md alignwide\">\n\t\t\t\t\t\t\t\t\t\t\n<div class=\"em-cta-card__wrapper icon-above\">\n\t<div class=\"em-cta-card__heading\">\n\t\t\t\t<img decoding=\"async\" src=\"https:\/\/firdapsehcp.com\/ca-lems\/wp-content\/uploads\/sites\/2\/2025\/07\/Group-15057.svg\" class=\"em-cta-card__icon\" \/>\n\t<\/div>\n\n\t<div class=\"em-cta-card__content\">\n\t\t\t\t\t<h3 class=\"em-cta-card__title\">Request a Rep<\/h3>\n\t\t\t\t<p>Connect with a FIRDAPSE<br \/>\nrepresentative.<\/p>\n\t<\/div>\n\n\t<div class=\"em-cta-card__btn-wrapper\">\n\t\t<a href=\"https:\/\/firdapsehcp.com\/ca-lems\/request-a-rep\/\" target=\"\" class=\"c-btn c-btn--fwd\">\n\t\t\tStart Request\t\t<\/a>\n\t<\/div>\n<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\n\n\n<div class=\"wp-block-emagine-column em-col-middle\">\t\t\t\t<div id=\"block_7bcab261dc1530dba5b7629ccee0bb5b\" class=\"wp-block em-cta-card em-mt--none em-mb--md alignwide\">\n\t\t\t\t\t\t\t\t\t\t\n<div class=\"em-cta-card__wrapper icon-above\">\n\t<div class=\"em-cta-card__heading\">\n\t\t\t\t<img decoding=\"async\" src=\"https:\/\/firdapsehcp.com\/ca-lems\/wp-content\/uploads\/sites\/2\/2025\/06\/Group-15261.svg\" class=\"em-cta-card__icon\" \/>\n\t<\/div>\n\n\t<div class=\"em-cta-card__content\">\n\t\t\t\t\t<h3 class=\"em-cta-card__title\">VGCC-Ab Test<\/h3>\n\t\t\t\t<p>Learn about an accurate test to confirm a<br \/>\nCancer-Associated LEMS SCLC diagnosis.<\/p>\n\t<\/div>\n\n\t<div class=\"em-cta-card__btn-wrapper\">\n\t\t<a href=\"https:\/\/firdapsehcp.com\/ca-lems\/vgcc-ab-test\/\" target=\"\" class=\"c-btn c-btn--fwd\">\n\t\t\tGo to VGCC-Ab Test\t\t<\/a>\n\t<\/div>\n<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n<\/div><\/div>\n","protected":false},"excerpt":{"rendered":"<p>The progressive nature of Cancer-Associated LEMS SCLC and the challenges that diagnosing it can present make early symptom recognition critical&#8230;<\/p>\n","protected":false},"author":2,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":true,"em_featured_video_id":0,"footnotes":""},"class_list":["post-41","page","type-page","status-publish","hentry"],"acf":[],"_links":{"self":[{"href":"https:\/\/firdapsehcp.com\/ca-lems\/wp-json\/wp\/v2\/pages\/41","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/firdapsehcp.com\/ca-lems\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/firdapsehcp.com\/ca-lems\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/firdapsehcp.com\/ca-lems\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/firdapsehcp.com\/ca-lems\/wp-json\/wp\/v2\/comments?post=41"}],"version-history":[{"count":0,"href":"https:\/\/firdapsehcp.com\/ca-lems\/wp-json\/wp\/v2\/pages\/41\/revisions"}],"wp:attachment":[{"href":"https:\/\/firdapsehcp.com\/ca-lems\/wp-json\/wp\/v2\/media?parent=41"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}